Glucocorticoid is any of a family of steroid hormones characterized by an ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by their specific receptors, target cells, and effects.

Both glucocorticoids and mineralocorticoids are classed as corticosteroids and originate in the cortex of the adrenal glands.