Growth hormone-releasing hormone (GHRH), also known as growth hormone-releasing factor (GRF or GHRF) or somatoliberin, is a 44-amino acid peptide hormone produced in the arcuate nucleus of the hypothalamus. Growth hormone-releasing hormone is released from neurosecretory nerve terminals of these arcuate neurons, and is carried by the hypothalamo-hypophysial portal circulation to the anterior lobe of the pituitary gland where it stimulates the production and secretion of growth hormone (GH).